The NPHS1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NPHS1, and NPHS1 nephrin. This antibody recognizes Human antigen. The NPHS1 Antibody has been validated for the following applications: Immunohistochemistry.
Description
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes